D-erythro-Sphingosine, N,N-Dimethyl--CAS 119567-63-4-Calbiochem

C₂₀H₄₁NO₂

327.55

A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

Cell permeable: yes
Product does not compete with ATP.
Target IC₅₀: 12 µM against PKC
Reversible: yes
Primary Target
PKC

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

oil (Clear)
waxy solid

Calbiochem^®

OK to freeze

DMSO: 5 mg/mL
ethanol: soluble
methanol: soluble

ambient

−20℃

1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1

YRXOQXUDKDCXME-YIVRLKKSSA-N

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 3