PRMT Inhibitor VII, DB867-Calbiochem

C₁₇H₁₅NO₅

313.30

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Primary Target
PRMT1
Reversible: yes

Toxicity: Standard Handling (A)

Xu, J., et al, 2013. Mol. Cell.51, 1.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

9 μM IC₅₀

Calbiochem^®

OK to freeze
protect from light

yellow

10% acetic acid: 5 mg/mL

2-8℃

Packaged under inert gas

11 - Combustible Solids

WGK 3