您的位置：首页 > 产品中心 > InSolution Vitamin D3, 1α, 25-Dihydroxy--Calbiochem
InSolution Vitamin D3, 1α, 25-Dihydroxy--Calbiochem
| 产品编号： | 4083392 |
| 规格： | A 1 mM (50 ug/112 μL) solution of Vitamin D3, 1α, 25-Dihydroxy- in DMSO |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Millipore |
| 优惠价： | 立即咨询 |
产品别名
InSolution Vitamin D3, 1α, 25-Dihydroxy--Calbiochem
1,25-(OH)2-D3
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H44O3 |
| Molecular weight | 416.64 |
| General description【一般描述】 | Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target vitamin D receptor |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | A 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA95, 15412. Hannun, Y.A. 1994. J. Biol. Chem.269, 3125. Mathieu, C., et al. 1994. Diabetologica37, 552. Thomasset, M. 1994. Pathol. Biol.42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189. Wakasugi, M., et al. 1991. Prostaglandins42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Assay【测定】 | ≥99% (HPLC) |
| Quality Level【质量水平】 | 200 |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
