Interferon-αA human

MFCD01635115

Interferon-αA human has been used to:

• study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
• study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
• compare the effect of Monascus pigment derivatives on hepatitis C virus replication

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Supplied as a solution in 5 mM sodium acetate, pH 4.0.

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

200

human

expressed in E. coli

≥95%

buffered aqueous solution

19 kDa

pkg of 20 μg

≥0.2 mg/mL

cell culture | mammalian: suitable

endotoxin, tested

colorless

P01563

wet ice

−20℃

human ... IFNA2(3440)

12 - Non Combustible Liquids

WGK 3

Eyeshields, Gloves