Leupeptin, Hemisulfate, Microbial-CAS 103476-89-7-Calbiochem

C₂₀H₃₈N₆O₄ · 0.5H₂SO₄

475.59

MFCD00037012

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV⁺ donors. Also available as a 50 mM solution in H₂O (Cat. No. 509281).
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV⁺ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.

Product does not compete with ATP.
Primary Target
trypsin- and cysteine-like proteases
Reversible: yes
Cell permeable: no

Toxicity: Standard Handling (A)

Ac-Leu-Leu-arginal, hemisulfate

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

200

≥90% (HPLC)

lyophilized solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: 50 mg/mL

ambient

−20℃

1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1

GDBQQVLCIARPGH-ULQDDVLXSA-O

50 mg in Glass bottle
100 mg in Plastic ampoule
5, 10, 25 mg in Plastic ampoule

11 - Combustible Solids

WGK 3