SB 203580, Hydrochloride-CAS 869185-85-3-Calbiochem

C₂₁H₁₆FN₃OS · xHCl

377.43 (free base basis)

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
p38 MAP kinase
Target IC₅₀: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

bright yellow

water: 10 mg/mL
DMSO: soluble

ambient

−20℃

1, 10 mg in Plastic ampoule

11 - Combustible Solids

WGK 3