α-Amyloid Precursor Protein Modulator-CAS 497259-23-1-Calbiochem

C₂₇H₃₀F₃N₃O₃

501.54

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
A cell-permeable PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target K_i: 11.9 nM for activating PKCα
Primary Target
PKC

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Kozikowski, A.P., et al. 2003. J. Med. Chem.46, 364.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

orange

methanol: 1 mg/mL
DMSO: 50 mg/mL

wet ice

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1