Tpl2 Kinase Inhibitor-CAS 871307-18-5-Calbiochem

C₂₁H₁₄ClFN₆

404.83

A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC₅₀ = 50 nM). Displays significant selectivity over other related kinases (IC₅₀ = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC₅₀ = 700 nM and 8.5 µM, respectively).

Cell permeable: yes
Target IC₅₀: 50 nM against Tpl2 kinase
Primary Target
Tpl2 Kinase
Product competes with ATP.
Reversible: yes

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5288.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow

DMSO: 10 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H315 - H319

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Eye Irrit. 2 - Skin Irrit. 2

11 - Combustible Solids

WGK 2