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Anti-phospho-c-Jun (pSer73) antibody produced in rabbit
| 产品编号： | 4063509 |
| 规格： | affinity isolated antibody, buffered aqueous glycerol solution |
| 包装规格： | 0.1 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD03703526 |
| NACRES | NA.41 |
| Specificity【特异性】 | The antibody does not react with non-phosphorylated c-Jun or JunD. It does react with the JunD phosphorylated at Ser100, a site conserved between c-Jun and JunD. |
| Immunogen【免疫原】 | synthetic phosphoserine73 peptide corresponding to residues around Ser73 of human c-Jun, conjugated to KLH. |
| Application【应用】 | Anti-phospho-c-Jun (pSer73) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus. |
| Biochem/physiol Actions【生化/生理作用】 | The protooncogene c-Jun encodes a member of the Jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes. |
| Physical form【外形】 | Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol |
| Preparation Note【制备说明】 | Purified using protein A and peptide affinity chromatography. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| species reactivity | mouse, human |
| technique(s) | microarray: suitable western blot (chemiluminescent): 1:1,000 using extract of mouse NIH3T3 anisomycin or UV-treated cells |
| UniProt accession no.【UniProt登记号】 | P05412 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... JUN(3725) mouse ... Jun(16476) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
