Histone Deacetylase Inhibitor III

C₁₆H₂₅N₃O₃

307.39

MFCD03453554

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

Cell permeable: yes
Primary Target
Rat liver HDAC
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 40 nM for rat liver HDAC

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753.
Jung, M., et al. 1999. J. Med. Chem.42, 4669.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 1 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1