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Anti-XPG (C-terminal) 兔抗
Anti-XPG (C-terminal) antibody produced in rabbit
| 产品编号： | 3406031 |
| 规格： | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-XPG (C-terminal) 兔抗
Anti-XPG (C-terminal) antibody produced in rabbit
Anti-COFS3
Anti-ERCC5
Anti-XPGC
Anti-ERCM2
Anti-UVDR
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-XPG (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue. Xeroderma pigmentosum group G (XPG) is a DNA repair gene, that is mapped to human chromosome13q33. It is a member of the FEN-1 family of structure-specific nucleases and contains two highly conserved nuclease motifs known as the N and I regions separated by a large insertion. This gene spans around 69kb in length and has15 exons. It is highly polymorphic. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue. |
| Application【应用】 | Anti-XPG (C-terminal) antibody produced in rabbit has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Xeroderma pigmentosum group G (XPG) helps to maintain genomic stability. It also participates in RNA transcription by interacting with TFIIH, RNA polymerase II and Gadd45a. XPG also participates in nucleotide excision repair (NER) pathway. Mutations in the XPG gene cause the Cockayne syndrome which is characterized by severe growth defects, mental retardation and cachexia. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | indirect immunofluorescence: 2-4 μg/mL using HEK-293T cells expressing recombinant XPG fusion protein, fixed with paraformaldehyde-Triton western blot: 1-2 μg/mL using whole cell lysates of COS7 cells expressing recombinant XPG fusion protein |
| UniProt accession no.【UniProt登记号】 | P28715 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ERCC5(2073) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
