Anti-Tryptophan Hydroxylase antibody produced in sheep

MFCD00282500

NA.41

The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.

recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.

Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:

• immunocytochemistry
• immunohistochemistry
• immunofluorescence
• immunoperoxidase staining

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

Solution in 150 mM NaCl, 10 mM HEPES, pH 7.5, 100 μg per mL BSA, and 50% glycerol.

200

sheep

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

sufficient for 10 blots

human, mammals

western blot: 1:1,000 using human dorsal raphe nucleus

P17752

wet ice

−20℃

human ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)

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