Anti-phospho-Tau (pSer^199/202) antibody produced in rabbit

MFCD03455771

NA.41

Tau proteins are known as microtubule-associated phosphoprotein (MAP) and express mainly in neurons of central nervous system. It has a crucial role in tubulin polymerization and facilitates microtubules assembly and stability. The biological activity of tau proteins depends on degree of its phosphorylation. Anti-phospho-Tau (pSer^199/202) antibody can be used in microarray and western blotting. It can also be used in immunoblotting. Rabbit anti- phospho-Tau (pSer^199/202) antibody reacts specifically with human Tau (pSer^199/202) (45-68 kD).
Tau (τ), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.

chemically synthesized phosphopeptide derived from the region of human tau that contains serine¹⁹⁹ and serine²⁰².

Anti-phospho-Tau (pSer^199/202) antibody (diluted 1:1000 in PBS containing 0.3% Triton X-100 and 0.5% BSA) can be used in immunocytochemistry for identification of protein aggregates. It can also be used as primary antibody (diluted 1: 3000) in immunohistochemistry.
Anti-phospho-Tau (pSer199/202) antibody produced in rabbit has been used in:

• immunocytochemistry
• immunohistochemistry
• western blot

Tau (τ) plays an essential role in the assembly and maintenance of microtubule structure. Deletion of tau (τ) results in developmental delay and learning disability. The gene expression is associated with the development of Alzheimer′s disease (AD). Genetic variation in τ gene increases the risk of susceptibility to the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration.

Solution in 100 μl Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, 50% glycerol, containing 1.0 mg/ml BSA (IgG, protease free) and 0.05% sodium azide. The amount of antibody is sufficient for 10 immunoblots.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

mouse, rat, human

microarray: suitable
western blot: suitable

P10636

wet ice

−20℃

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

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GHS07

Warning

H315 - H319

P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2

10 - Combustible liquids

WGK 3

320.0 °F - closed cup

160 ℃ - closed cup