Anti-LIN28B (N-term) antibody produced in rabbit

NA.41

Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

LIN28B (NP_001004317, 14-43)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human LIN28B.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

Ig fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

human

indirect ELISA: 1:1000
western blot: 1:100-1:500

NP_001004317

Q6ZN17

dry ice

−20℃

human ... LIN28B(389421)

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12 - Non Combustible Liquids

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