ANTI-ISL1 antibody produced in mouse

NA.41

Insulin gene enhancer binding protein-1 (ISL-1) gene spanning 220kb of genomic DNA, is mapped to human chromosome 5q11.1. The gene codes for a member of LIM zinc-binding/homeobox-domain transcription factor and is predominantly expressed in hindbrain, forebrain, ventral neural tube, dorsal root ganglia (DRG) and trigeminal ganglia.

ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP

Insulin gene enhancer binding protein-1 (ISL-1) is a transcription factor which plays a vital role in the development of the heart, motor neurons and pancreas. It also stimulates adult pancreatic ß-cells proliferation. ISL1 might also be involved in the regulation of insulin expression. Elevated expression of the gene has been observed in patients with gastric cancer. Thus, the protein can be used as a potential biomarker and therapeutic target for gastric cancer. Mutation in the gene is associated with the increased risk of susceptibility to human congenital heart disease (CHD).

Solution in phosphate buffered saline, pH 7.4

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

8A3, monoclonal

buffered aqueous solution

antigen 36.41 kDa

human

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

IgG2aκ

NM_002202

P61371

dry ice

−20℃

human ... ISL1(3670)

12 - Non Combustible Liquids