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Anti-GUCY2C (981-995) antibody produced in rabbit
| 产品编号： | 3366587 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-GUCY2C (981-995) antibody produced in rabbit
Anti-guanylate cyclase 2C (heat stable enterotoxin receptor)
Anti-GUC2C
Anti-STAR
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The guanylate cyclase 2C (GUCY2C) gene is mapped to human chromosome 12p12. The gene codes for a transmembrane receptor guanylate cyclase C (GC-C) and is expressed in intestine. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 981-995 of human GUCY2C |
| Application【应用】 | Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. |
| Biochem/physiol Actions【生化/生理作用】 | Guanylate cyclase 2C (GUCY2C) converts guanosine-5′-triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), upon binding of its ligand guanylin and uroguanylin, which are paracrine hormones. GUCY2C functions as a tumor suppressor and hinders intestinal tumorigenesis by inhibiting the protein kinase B/AKT signaling pathway. Transmembrane receptor guanylate cyclase C (GC-C) regulates the secretion of chloride. Alteration in the gene expression leads to congenital sodium diarrhoea (CSD). |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~123 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:500-1:2,000 |
| UniProt accession no.【UniProt登记号】 | P25092 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GUCY2C(2984) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
