Anti-EGFR antibody produced in rabbit

NA.41

Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor-α (TGF-α), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2. Anti-EGFR Antibody detects endogenous levels of total EGFR protein.

The antiserum was produced against synthesized peptide derived from human EGFR.

Immunogen Range: 1139-1188

Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 134 kDa

rat, mouse, human

~1 mg/mL

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

P00533

P00533

wet ice

−20℃

human ... EGFR(1956)

12 - Non Combustible Liquids

nwg