您的位置：首页 > 产品中心 > Anti-Calcium Channel (β4 Subunit) (Voltage Gated Ca2+ Channel) antibody produced in rabbit
Anti-Calcium Channel (β4 Subunit) (Voltage Gated Ca2+ Channel) antibody produced in rabbit
| 产品编号： | 3350551 |
| 规格： | ~1 mg/mL, fractionated antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD04974685 |
| NACRES | NA.41 |
| General description【一般描述】 | The gene CACNB4 (Calcium channel voltage-dependent subunit beta 4) is mapped to human chromosome 2q22-23. It is present at the membrane as well as the nucleus. |
| Specificity【特异性】 | Specifically recognizes a splice variant of β4 (55 kDa). |
| Immunogen【免疫原】 | synthetic peptide derived from the rat β4 calcium channel subunit conjugated to KLH. |
| Application【应用】 | Anti-Calcium Channel (β-4 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using brain tissue lysate. The antibody has been used for:
|
| Biochem/physiol Actions【生化/生理作用】 | The CACNB4 (Calcium channel voltage-dependent subunit β 4) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. Mutations in CACNB4 are associated with idiopathic generalized epilepsy and episodic ataxia. CACNB4 interacts with heterochromatin protein 1γ (HP1γ). The interaction attenuates the gene silencing activity by HP1. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.08% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | fractionated antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | western blot: 5-10 μg/mL using brain tissue lysate |
| UniProt accession no.【UniProt登记号】 | O00305 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CACNB4(785) mouse ... Cacnb4(12298) rat ... Cacnb4(58942) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
