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Zardaverine
| 产品编号： | 3260952 |
| 规格： | phosphodiesterase inhibitor |
| CAS NO： | 101975-10-4 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
101975-10-4
Zardaverine
6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H10F2N2O3 |
| Molecular weight | 268.22 |
| MDL number | MFCD00867059 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278784 |
| NACRES | NA.77 |
| Application【应用】 | Zardaverine has been used as a phosphodiesterase inhibitor:
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| Biochem/physiol Actions【生化/生理作用】 | Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma. Selective inhibitor of phosphodiesterase III/IV (PDE3/4). |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | synthetic (organic) |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| potency【效能】 | 1.1 μM IC50 (for PDE IV) 2.5 μM IC50 (for PDE III) |
| SMILES string | COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2 |
| InChI | 1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) |
| InChI key | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
| Gene Information | human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
