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Z36
产品别名
Z36
1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
(Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H24FN3O2 |
| Molecular weight | 393.45 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825205 |
| NACRES | NA.77 |
| Application【应用】 | Z36 may be used to study cell signaling that results in autophagy. |
| Biochem/physiol Actions【生化/生理作用】 | Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1. Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | light yellow to dark yellow |
| solubility【溶解性】 | DMSO: ≥15 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1 |
| InChI | 1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11- |
| InChI key | CQNOITUXWKRVMB-JAIQZWGSSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
