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WKYMVM trifluoroacetate salt
产品别名
187986-11-4
WKYMVM trifluoroacetate salt
Trp-Lys-Tyr-Met-Val-L-Met NH2 trifluoroacetate salt
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C41H61N9O7S2 · xC2HF3O2 |
| Molecular weight | 856.11 (free base basis) |
| MDL number | MFCD19443869 |
| PubChem Substance ID【PubChem化学物质编号】 | 329830691 |
| NACRES | NA.32 |
| Amino Acid Sequence | Trp-Lys-Tyr-Met-Val-L-Met NH2 |
| Application【应用】 | WKYMVM trifluoroacetate salt was used as a test compound for investigating the mechanism of regulation of lipoprotein-associated phospholipase A2 (Lp-PLA2). |
| Biochem/physiol Actions【生化/生理作用】 | WKYMVM is a peptide agonist of formyl peptide receptors. WKYMVM binds to and stimulates FPRL family members 1, 2 with EC50 values of 2 and 80 nM, respectively. The peptide is a potent activator of neutrophils. WKYMVM is an agonist and potent activator of Formyl peptide receptor like-1 (FPRL1). WKYMVM stimulates FPRL1 and hence attenuates the function of the chemokine receptors CCR5 and CXCR4. WKYMVM activates human eosinophils to induce superoxide production through Phosphoinositide 3-Kinase-Mediated ERK1/2 pathway. |
| Preparation Note【制备说明】 | WKYMVM trifluoroacetate salt dissolves in water at a concentration >2 mg/mL to yield a clear solution. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: >2 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)C(C)C)C(N)=O |
| InChI | 1S/C41H61N9O7S2.C2HF3O2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30;3-2(4,5)1(6)7/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55);(H,6,7)/t29-,31-,32-,33-,34-,35-;/m0./s1 |
| InChI key | MYVYQWVNXDVTBW-CZPFDPCBSA-N |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
