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RRD-251 hydrochloride
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3215861 | 5 MG | 587 | |||
| 3215861 | 25 MG | 2660 |
产品别名
72214-67-6
RRD-251 hydrochloride
(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride
S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride
Rb/Raf-1 disruptor 251 hydrochloride
2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H8Cl2N2S· HCl |
| Molecular weight | 271.59 |
| MDL number | MFCD00035047 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823647 |
| Biochem/physiol Actions【生化/生理作用】 | RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: >2 mg/mL |
| storage temp.【储存温度】 | room temp |
| SMILES string | Cl.NC(=N)SCc1ccc(Cl)cc1Cl |
| InChI | 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| InChI key | COMNQRICZGJVLE-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
