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PrEST Antigen CHRM1
| 产品编号： | 3193986 |
| 规格： | Prestige AntigensTM Powered by Atlas Antibodies, buffered aqueous solution |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品性质
| Quality Level【质量水平】 | 100 |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | >80% (SDS-PAGE) |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | predicted mol wt 32 kDa |
| purified by【纯化方式】 | immobilized metal affinity chromatography (IMAC) |
| concentration【浓度】 | ≥0.5 mg/mL |
| immunogen sequence【免疫原序列】 | SETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE |
| Ensembl | human accession no.【基因组数据库 |人类登记号】 | ENSG00000168539 |
| UniProt accession no.【UniProt登记号】 | P11229 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CHRM1(1128) |
基本信息
| General description【一般描述】 | Recombinant protein fragment of Human CHRM1 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. Cholinergic receptor, muscarinic 1 (CHRM1) is also known as muscarinic acetylcholine receptor M1 (mAChRs). It encoded by gene CHRM1 located on human chromosome 11q12.3. Cholinergic receptor, muscarinic 1 (CHRM1) belongs to G protein-coupled receptors and comprises of 5 subtypes: M1 to M5. |
| Application【应用】 | Suitable as a blocking agent using corresponding antibodies. |
| Biochem/physiol Actions【生化/生理作用】 | CHRM1 is activated by acetylcholine and it regulates multitude of physiological processes of the central and peripheral nervous system. It is also associated with learning, cognition and memory. CHRM1 is allosterically regulated and is a prime target for drug design in disorders of central nervous system. CHRM1 receptor modulation improves cognitive function. Elevated levels of CHRM1- acetylcholine complex is observed in patients with Alzheimer′s disease. Single polynucleotide polymorphisms in CHRM1 is observed in patients with schizophrenia. Mutations in the CHRM1 gene locus is associated with facial impairment and developmental delay. |
| Linkage【联系】 | Corresponding Antibody HPA014101. |
| Physical form【外形】 | Solution in 1 M urea-PBS, pH 7.4 |
| Preparation Note【制备说明】 | The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user. |
| Legal Information【法律信息】 | Prestige Antigens is a trademark of sigma-aldrich Co. LLC |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
