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Monoclonal Anti-GFRA1 antibody produced in mouse

产品编号:3145596
规格:clone 1G4, purified immunoglobulin, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3145596100 μG4470
产品别名

Monoclonal Anti-GFRA1 antibody produced in mouse

Anti-TRNR1

Anti-RET1L

Anti-MGC23045

Anti-GDNFRA

Anti-GDNFR

Anti-RETL1

Anti-GDNF family receptor alpha 1

Anti-GFRALPHA1

基本信息
MDL number
MFCD01865527
NACRES
NA.41
General description【一般描述】
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. (provided by RefSeq).
Glial cell derived neurotrophic factor (GDNF) family receptor alpha 1 (GFRA1) gene is located on human chromosome 10q25.3. GFRA1 is the co-receptor for GDNF. GFRA1 is expressed in spermatogonia.
Immunogen【免疫原】
GFRA1 (NP_005255, 32 a.a. ~ 119 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
ASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDS
Biochem/physiol Actions【生化/生理作用】
Glial cell derived neurotrophic factor (GDNF) family receptor alpha 1 (GFRA1) regulates progression and metastasis of breast and pancreatic cancer and thereby, promotes migration and invasion. Deficiency of GFRA1 in Alzheimer′s neurons is linked to neuronal death. GFRA1 helps in the GDNF-induced replication of spermatogonial stem cells (SSCs). It is important for spermatogonial development.
Physical form【外形】
Solution in phosphate buffered saline, pH 7.4
Legal Information【法律信息】
GenBank is a registered trademark of United States Department of Health and Human Services
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
1G4, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype【同位素/亚型】
IgG2aκ
GenBank® accession no.
NM_005264
UniProt accession no.【UniProt登记号】
P56159
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... GFRA1(2674)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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