Monoclonal Anti-DYNLT1 antibody produced in mouse

NA.41

recombinant dynein 1 light chain-myosin basic protein fusion protein.

Monoclonal Anti-DYNLT1 antibody produced in mouse is suitable for immunocytochemistry and immunoblotting at a working concentration of 8-16μg/mL using NRK total cell lysate.

Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT1 is a light chain subunit of the complex that is involved in cargo binding. It binds specifically to the cytoplasmic tail of rhodopsin and links rhodopsin-bearing vesicles to the dynein motor complex for transport. The cargo is released by the disassembly of dynein complex upon phosphorylation of DYNLT1 on Ser⁸² residue. This process is critical for the apical delivery of membrane cargoes. It also mediates neurite extension by modulating actin dynamics and also Rac1 activity. The abundance and expression pattern of DYNLT1 in neuronal tissues may also contribute to the invasion capabilities of neurotropic viruses like poliovirus.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

T1, monoclonal

buffered aqueous solution

antigen ~12.5 kDa

mouse, human, bovine, rat, monkey

~1.0 mg/mL

immunocytochemistry: suitable
western blot: 8-16 μg/mL using NRK total cell lysate

IgG1

P63172

dry ice

−20℃

human ... DYNLT1(6993)
mouse ... Dynlt1(21648)
rat ... Dynlt1(83462)

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