Monoclonal Anti-CD71 antibody produced in mouse

NA.41

The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.
Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.

NALM-6 human pre-B cell line

Monoclonal Anti-CD71 antibody produced in mouse has been used in co-immunoprecipitation assay.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

MEM-75, monoclonal

buffered aqueous solution

human

1 mg/mL

flow cytometry: suitable

IgG1

NM_001128148.1

P02786

wet ice

2-8℃

human ... TFRC(7037)

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12 - Non Combustible Liquids