Monoclonal Anti-CD44 antibody produced in rat

NA.41

The CD44 (cell-surface glycoprotein) gene with 20 exons is mapped to human chromosome 11p13. The gene codes for a transmembrane glycoprotein.
The rat monoclonal antibody IM7 reacts with CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.

Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Monoclonal Anti-CD44 antibody produced in rat has been used in immunohistochemistry.

CD44 (cell-surface glycoprotein) is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer. Overexpression of CD44 leads to esophageal squamous cell carcinoma (ESCC). CD44 inhibits macrophage multinucleation by interacting with its ligands, hyaluronic acid, chondroitin sulfates and osteopontin. 100kDa form of CD44, facilitates the binding of poliovirus to HeLa cells. In addition, it also implicated in the infection of mononuclear phagocytes by human immunodeficiency virus (HIV).

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

100

rat

unconjugated

purified immunoglobulin

primary antibodies

IM7, monoclonal

buffered aqueous solution

human, canine, feline, mouse, horse

1 mg/mL

flow cytometry: suitable

IgG2b

NM_000610.3

P16070

wet ice

2-8℃

human ... CD44(960)

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12 - Non Combustible Liquids