2'-脱氧鸟苷 一水合物

C₁₀H₁₃N₅O₄ · H₂O

285.26

39814

MFCD00150760

24894083

NA.51

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:

• to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
• in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
• in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s). Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

200

synthetic (organic)

99-100%

powder

1 M NH₄OH: 50 mg/mL, clear, colorless

O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

LZSCQUCOIRGCEJ-FPKZOZHISA-N

1, 5 g in poly bottle
25, 100 mg in poly bottle

13 - Non Combustible Solids

WGK 3