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LY225910
产品别名
133040-77-4
LY225910
2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H24BrN3O2 |
| Molecular weight | 502.40 |
| MDL number | MFCD00907856 |
| PubChem Substance ID【PubChem化学物质编号】 | 329817399 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission. LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia. |
| Features and Benefits【特点和优势】 | This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| originator【创始人】 | Eli Lilly |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C)Oc1cccc(c1)N2C(CCc3c[nH]c4ccc(Br)cc34)=Nc5ccccc5C2=O |
| InChI | 1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3 |
| InChI key | KUECXUACQOYKNB-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H413 |
| Precautionary Statements | P273 - P301 + P310 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 638.6 - 762.1 °F |
| Flash Point(C)【闪点(C)】 | 337 - 405.6 ℃ |
